Search results for "Melanotan II"

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Functional Evaluation of THIQ, a Melanocortin 4 Receptor Agonist, in Models of Food Intake and Inflammation

2007

The central melanocortinergic system plays an important role in regulating different aspects of energy homeostasis and the immunomodulatory response. In the present study, we evaluated the in vivo activities of food intake suppression and anti-inflammatory activity of THIQ, which has been proposed to possess high and selective melanocortin-4 receptor agonistic activity in vitro. The results showed that THIQ (0.1, 0.3 and 1 nmol/rat, intracerebroventricularly) is less effective in reducing food intake and body weights of rats than the non-selective melanocortin receptor agonist melanotan II. Electron paramagnetic resonance measurements in mice brain tissue showed that THIQ at doses of 0.001 …

LipopolysaccharidesMaleAgonistmedicine.medical_specialtymedicine.drug_classAnti-Inflammatory AgentsBiologyNitric OxideToxicologyPeptides CyclicEnergy homeostasisEatingMiceMelanocortin receptorIn vivoTetrahydroisoquinolinesInternal medicinemedicineAnimalsRats WistarReceptorInjections IntraventricularInflammationPharmacologyMice Inbred ICRDose-Response Relationship DrugBody Weightdigestive oral and skin physiologyElectron Spin Resonance SpectroscopyBrainMelanotan IIGeneral MedicineTriazolesRatsMelanocortin 4 receptorDisease Models AnimalEndocrinologyalpha-MSHTHIQReceptor Melanocortin Type 4medicine.drugBasic & Clinical Pharmacology & Toxicology

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